03865cam a2200397 i 450000100090000000300080000900500170001700700030003400800410003701000170007802000290009502000260012404000280015004100080017804200080018605000250019408200080021910000500022724501500027725000410042726400360046830000480050433600260055233700280057833800270060650400670063350503320070052017930103252003590282565000250318465000150320965000360322465000160326070000250327677601660330120861424BJBSDDR20240401111100.0ta190221s2019    nyua     b    001 0 eng    a  2019007196  a9781501191978 (hardback)  a1501191977 (hardback)  aDLCbengcDLCerdadDLC  aeng  apcc14aQH 528.5bS616l 201900a5701 aSinclair, David A. q(David Andrew), d1969- 10aLifespan :bwhy we age--and why we don't have to /cDavid A. Sinclair, PhD, AO, with Matthew D. LaPlante ; illustrations by Catherine L. Delphia.  aFirst Atria Books hardcover edition. 1aNew York :bAtria Books,c2019.  axxiii, 406 pages :billustrations ;c24 cm.  atextbtxt2rdacontent  aunmediatedbn2rdamedia  avolumebnc2rdacarrier  aIncludes bibliographical references (pages 315-367) and index.0 aIntroduction: A grandmother's prayer
What we know (the past). Viva Primordium ; The demented pianist ; The blind epidemic
What we're learning (the present). Longevity now ; A better pill to swallow ; Big steps ahead ; The age of innovation
Where we're going (the future). The shape of things to come ; A path forward
Conclusion  a"From an acclaimed Harvard professor and one of Time's most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated.  For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes--the kind that inevitably happens as we get older--makes us become sick and grow old.  But what if everything you think you know about aging is wrong? What if aging is a disease--and that disease is treatable?   In Lifespan, one of the world's foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn't immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclair's own lab--that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes--the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, and exercising with the right intensity--that have been shown to help lead to longer lives.  Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young"--cProvided by publisher.  a"From an acclaimed Harvard professor and one of Time's most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated"--cProvided by publisher. 0aLife spans (Biology) 0aLongevity. 4aEsperanza de vida (Biología)  4aLongevidad.1 aLaPlante, Matthew D.08iOnline version:aSinclair, David A., 1969- author.tLifespanbFirst Atria Books hardcover edition.dNew York : Atria Books, 2019z9781501191992w(DLC) 2019009229