Robustness and evolvability in living systems /
Andreas Wagner.
- Princeton, N.J. : Princeton University Press, c2005.
- xii, 367 p. : ill. ; 24 cm.
- Princeton studies in complexity .
Includes bibliographical references (p. [323]-358) and index.
Introduction -- The genetic alphabet -- The genetic code -- RNA structure -- Proteins and point mutations -- Proteins and recombination -- Regulatory DNA regions and their reorganization in evolution -- Metabolic pathways -- Metabolic networks -- Drosophila segmentation and other gene regulatory networks -- Phenotypic traits, cryptic variation, and human diseases -- The many ways of building the same body -- Neutral spaces -- Evolvability and neutral mutations -- Redundancy of parts or distributed robustness? -- Robustness as an evolved adaptation to mutations -- Robustness as an evolved adapatation to environmental change and noise -- Robustness and fragility: advantages to variation and trade-offs -- Robustness in natural systems and self-organization -- Robustness in man-made systems.